DHRS11-IN-1 is an inhibitor of the short-chain dehydrogenase/reductase family member 11 (DHRS11), with an IC50 value of 0.037 μM. It binds to DHRS11 and forms a hydrogen bond with the His210 residue of the enzyme. DHRS11-IN-1 suppresses androgen receptor mRNA and protein expression, reduces c-Myc levels, and inhibits cancer cell proliferation. It also impedes the PI3K/AKT signaling pathway by decreasing the phosphorylation of PDK1, AKT, mTOR, and ERK. Additionally, DHRS11-IN-1 enhances Capivasertib-induced cytotoxicity and apoptosis (apoptosis). This compound can be applied in studies related to luminal androgen receptor-positive triple-negative breast cancer.