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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Cyclo(Phe-Gly)

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货号 TN6682Cas号 5037-75-2

Cyclo(Phe-Gly) shows weak antagonistic activity against VEGFR2 -CD, it also shows strong inhibitory activity against human cancer cells(KB,KBv200) with LD50 at 6.5 and 11.2 umol/L,respectively.

Cyclo(Phe-Gly)

Cyclo(Phe-Gly)

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货号 TN6682Cas号 5037-75-2

Cyclo(Phe-Gly) shows weak antagonistic activity against VEGFR2 -CD, it also shows strong inhibitory activity against human cancer cells(KB,KBv200) with LD50 at 6.5 and 11.2 umol/L,respectively.

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10 mg
¥ 4,370
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产品介绍

生物活性
产品描述
Cyclo(Phe-Gly) shows weak antagonistic activity against VEGFR2 -CD, it also shows strong inhibitory activity against human cancer cells(KB,KBv200) with LD50 at 6.5 and 11.2 umol/L,respectively.
体外活性

To discover antagonists of VEGFR2-CD from the fermentation broth produced by streptomyces strain I06A-02832. METHODS AND RESULTS:Under the guidance of ELISA assay against VEGFR2-CD, Compounds 2832 B and 2832 C were isolated and purified by combination of different column chromatographies and HPLC. The structures of compounds 2832 B and C were identified by combination of analysis of UV, IR, MS and 1D-NMR, 2D-NMR. Compounds 2832 B and 2832 C were purified and structurally identified as cyclic dipeptides, and were the same with cyclo-(Pro-Tyr) and Cyclo(Phe-Gly) respectively. Compounds 2832 B and 2832 C showed weak antagonistic activity against VEGFR2-CD by ELISA assay. CONCLUSIONS: They are firstly reported compounds 2832 B and 2832 C had antagonistic activity against VEGFR2-CD.

化学信息
分子量204.23
分子式C11H12N2O2
CAS No.5037-75-2
SmilesO=C1NC(C(=O)NC1)CC=2C=CC=CC2
密度1.202g/cm3
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

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TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

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剂量转换

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关键词

Cyclo(Phe-Gly)Cyclo(PheGly)Cyclo(Phe Gly)
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