规格

价格

库存

数量

500 μg

¥ 1,650

现货

1 mg

¥ 2,650

现货

生物活性

产品描述	Cladosporin is a metabolite derived from the mycelium of Cladosporium cladosporioides. Cladosporin inhibits the growth of several dermatophytes on agar medium at a concentration of 75 µg/mL, demonstrating potent antifungal activity. The biological properties of Cladosporin support the utilization of Cladosporin in studies of fungal biology, natural product research, antifungal mechanism characterization, and microbial growth regulation.
靶点活性 (IC₅₀)	human lysyl-tRNA synthetase:20 μM, lysyl-tRNA synthetase (Plasmodium falciparum):61 nM
体外活性	方法：在氨酰化试验中，采用重组恶性疟原虫胞质赖氨酰-tRNA合成酶和人赖氨酰-tRNA合成酶检测cladosporin。[1] 结果：Cladosporin抑制恶性疟原虫酶的IC50约为61 nM，而对人源酶的IC50大于20 μM，显示明显的生化选择性。[1] 方法：检测cladosporin对疟原虫血液期和肝期虫体的作用，并使用HepG2-CD81细胞评价宿主细胞毒性。[1] 结果：Cladosporin在约40-90 nM抑制虫体生长，而在低于10 μM时未检测到对HepG2-CD81宿主细胞的毒性，显示较大的虫体与宿主选择性窗口。[1]
别名	枝孢菌素

化学信息

储存&溶解度

存储

Store under nitrogen, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 20 mg/mL (68.42 mM), Sonication is recommended.

溶液配制表

DMSO

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Cladosporin