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CAY10580是一种选择性的前列腺素EP4受体激动剂 (Ki=35 nM)和PGE2类似物,能够预防饮食引起的高胆固醇血症。

CAY10580是一种选择性的前列腺素EP4受体激动剂 (Ki=35 nM)和PGE2类似物,能够预防饮食引起的高胆固醇血症。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 500 μg | ¥ 1,790 | 35日内发货 | |
| 1 mg | ¥ 3,360 | 35日内发货 | |
| 5 mg | ¥ 13,900 | 35日内发货 | |
| 10 mg | ¥ 24,500 | 35日内发货 |
| 产品描述 | CAY10580 is a selective prostaglandin EP4 receptor agonist (Ki=35 nM) and PGE2 analog that prevents diet-induced hypercholesterolemia. |
| 靶点活性 | EP2 receptor:3000 nM (Ki), EP4 receptor:35 nM (Ki), EP3 receptor:2000 nM (Ki), EP1 receptor:>3000 nM (Ki) |
| 体外活性 | CAY10580(200 μg/kg;腹腔注射;每天一次,持续三周) 能够预防饮食引起的高胆固醇血症,增强内源性胆汁酸合成和粪便排泄[3]。 |
| 体内活性 | CAY10580 (200 μg/kg body weight; i.p; daily for three weeks) effectively prevents diet-induced hypercholesterolemia, enhances endogenous bile acid synthesis and their fecal excretion[3]. Animal Model: Six-week old male EP4 +/+ mice (Treating high fat diet-challenged mice)[3]Dosage: 200 μg/kg body weight Administration: Intraperitoneal injection; daily for remaining three weeks Result: High fat diet fed mice exhibited lower total cholesterol levels compared to the vehicle group by 28.5%. Total cholesterol levels decreased from 137.4 to 98.2 mg/dl, restoring plasma cholesterol back to near-normal values. |
| 分子量 | 341.49 |
| 分子式 | C19H35NO4 |
| CAS No. | 64054-40-6 |
| Smiles | O=C(O)CCCCCCN1C(=O)CCC1CCC(O)CCCCC |
| 存储 |
对于不同动物的给药剂量换算,您也可以参考 更多