Azido-PEG6-NHS ester is a cleavable 6 unit polyethylene glycol (PEG) linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1]. Additionally, it serves as a PEG- and alkyl ether based linker for the synthesis of proteolysis targeting chimeras (PROTACs)[2].
N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker employed in the synthesis of PROTACs and antibody-drug conjugates (ADCs) [1, 2]. It acts as a cleavable ADC linker, facilitating the conjugation of drugs to antibodies for targeted delivery [2].
Azido-PEG4-CH2-Boc is a four-unit cleavable polyethylene glycol (PEG) linker compound employed in the synthesis of antibody-drug conjugates (ADCs)[1] and PROTACs[2]. This linker is characterized by its azide functional group and PEG backbone, facilitating the conjugation of drugs to antibodies in ADC development and enabling the synthesis of PROTACs utilizing PEG and alkyl ether moieties.
Propargyl-PEG2-NHBoc is a cleavable ADC linker utilized for the synthesis of antibody-drug conjugates (ADCs). This PEG-based PROTAC linker, namely Propargyl-PEG2-NHBoc, holds potential for the synthesis of PROTACs[1].
N3-PEG3-CH2CH2-Boc is a cleavable 3 unit polyethylene glycol (PEG) ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1]. This compound also functions as a PEG- and alkyl ether-based PROteolysis TArgeting Chimera (PROTAC) linker, suitable for the construction of PROTAC molecules[2].
Azido-PEG8-NHS ester is an 8 unit PEG linker with cleavable properties, commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1]. This compound also serves as a PEG- and Alkyl ether-based PROTAC linker, enabling its utilization in the synthesis of PROTACs[2].
BCN-PEG3-Val-Cit is a PEG-based linker commonly employed in PROTAC synthesis[1]. Additionally, it serves as a cleavable 3 unit PEG linker in the production of antibody-drug conjugates (ADCs)[2].
Boc-NH-PEG1-CH2CH2COOH is a cleavable ADC linker, possessing one unit of PEG, that can be utilized for the synthesis of antibody-drug conjugates (ADCs) and PROTACs. Additionally, it serves as a PEG- and Alkyl ether-based PROTAC linker [1][2].
Boc-gly-PEG3-endo-BCN is a PEG-based PROTAC linker and a cleavable 2-unit PEG ADC linker, utilized in the synthesis of PROTACs[1] and antibody-drug conjugates (ADCs)[2], respectively.
sulfo-SPDB is a cleavable linker vital in ADC synthesis. sulfo-SPDB joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.