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Anti-VE-Cadherin Antibody (3L899)
还可以产品编号 TMAY-03800
Anti-VE-Cadherin Antibody (3L899) 是一种 Mouse 抗体，靶向 VE-Cadherin。Anti-VE-Cadherin Antibody (3L899) 可用于 WB。
Anti-VE-Cadherin Antibody (3L899)
Anti-VE-Cadherin Antibody (3L899)
还可以产品编号 TMAY-03800
Anti-VE-Cadherin Antibody (3L899) 是一种 Mouse 抗体，靶向 VE-Cadherin。Anti-VE-Cadherin Antibody (3L899) 可用于 WB。
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| 产品描述 | Anti-VE-Cadherin Antibody (3L899) is a Mouse antibody targeting VE-Cadherin. Anti-VE-Cadherin Antibody (3L899) can be used in WB. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 3L899 |
| 交叉反应 | Rat |
| 验证活性 | Anti-CDH5 mouse monoclonal antibody at 1:500 dilution. -Lane A: A549 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:88 kDa. -Observed band size:78 kDa |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-1:1000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat VE-Cadherin / CD144 / CDH5 (rR VE-Cadherin / CD144 / CDH5; TMPY-03305; NP_001100877.1; Met1-Gln585). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Rat VE-Cadherin / CD144 / CDH5 protein (TMPY-03305) |
| 抗原种属 | Rat |
| 研究领域 | Hemangioblast Markers, Cardiac Stem Cell Markers |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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