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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-Transferrin Receptor/TFRC Antibody (2Q331)

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货号 TMAH-01165

别名 TR, TFRC, TfR1, TFR, T9, sTfR, p90, CD71

Anti-Transferrin Receptor/TFRC Antibody (2Q331) 是一种抗体，靶向 Transferrin Receptor/TFRC。Anti-Transferrin Receptor/TFRC Antibody (2Q331) 可用于 ELISA。

Anti-Transferrin Receptor/TFRC Antibody (2Q331)

Anti-Transferrin Receptor/TFRC Antibody (2Q331)

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Rating icon 还可以
货号 TMAH-01165 别名 TR, TFRC, TfR1, TFR, T9, sTfR, p90, CD71

Anti-Transferrin Receptor/TFRC Antibody (2Q331) 是一种抗体，靶向 Transferrin Receptor/TFRC。Anti-Transferrin Receptor/TFRC Antibody (2Q331) 可用于 ELISA。

规格价格库存数量
50 μL
¥ 1,300
5日内发货
100 μL
¥ 2,195
5日内发货
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产品介绍

生物活性
产品描述
Anti-Transferrin Receptor/TFRC Antibody (2Q331) is an antibody targeting Transferrin Receptor/TFRC. Anti-Transferrin Receptor/TFRC Antibody (2Q331) can be used in ELISA.
别名TR, TFRC, TfR1, TFR, T9, sTfR, p90, CD71
Ig Type
Human IgG1
克隆号
2Q331
反应种属
Human
验证活性
The Binding Activity of Human TFRC with Anti-TFRC Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TFRC at 2 μg/mL can bind Anti-TFRC recombinant antibody, the EC50 is 3.305-8.220 ng/mL.
应用ELISA
抗体种类
Monoclonal
亚细胞定位Cell membrane; Single-pass type II membrane protein. Melanosome.; [Transferrin receptor protein 1, serum form]: Secreted.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
研究背景Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2. (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human TFRC Protein
抗原种属
Human
基因名称
TFRC
基因ID
7037
Uniprot ID
P02786
研究领域
Cancer, Cardiovascular, Immunology, Metabolism, Stem cells
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器

关键词

T-9T 9CD-71CD 71
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