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Anti-Transferrin Receptor/TFRC Antibody (2Q331)
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产品编号 TMAH-01165
别名 TR, TFRC, TfR1, TFR, T9, sTfR, p90, CD71
Anti-Transferrin Receptor/TFRC Antibody (2Q331) 是一种抗体，靶向 Transferrin Receptor/TFRC。Anti-Transferrin Receptor/TFRC Antibody (2Q331) 可用于 ELISA。
Anti-Transferrin Receptor/TFRC Antibody (2Q331)
Anti-Transferrin Receptor/TFRC Antibody (2Q331)
还可以产品编号 TMAH-01165 别名 TR, TFRC, TfR1, TFR, T9, sTfR, p90, CD71
Anti-Transferrin Receptor/TFRC Antibody (2Q331) 是一种抗体，靶向 Transferrin Receptor/TFRC。Anti-Transferrin Receptor/TFRC Antibody (2Q331) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,195 | 5日内发货 |
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产品介绍
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抗原信息
| 产品描述 | Anti-Transferrin Receptor/TFRC Antibody (2Q331) is an antibody targeting Transferrin Receptor/TFRC. Anti-Transferrin Receptor/TFRC Antibody (2Q331) can be used in ELISA. |
| 别名 | TR, TFRC, TfR1, TFR, T9, sTfR, p90, CD71 |
| Ig Type | Human IgG1 |
| 克隆号 | 2Q331 |
| 交叉反应 | Human |
| 验证活性 | The Binding Activity of Human TFRC with Anti-TFRC Recombinant Antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TFRC at 2 μg/mL can bind Anti-TFRC recombinant antibody, the EC50 is 3.305-8.220 ng/mL. |
| 应用 | |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell membrane; Single-pass type II membrane protein. Melanosome.; [Transferrin receptor protein 1, serum form]: Secreted. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 研究背景 | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2. (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human TFRC Protein |
| 抗原种属 | Human |
| 基因ID | |
| Uniprot ID | |
| 研究领域 | Cancer, Cardiovascular, Immunology, Metabolism, Stem cells |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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