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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-TLR8 Polyclonal Antibody

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货号 TMAB-01860

别名 Toll-like receptor 8, TLR8, CD288

Anti-TLR8 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 TLR8。Anti-TLR8 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P,WB。

Anti-TLR8 Polyclonal Antibody

Anti-TLR8 Polyclonal Antibody

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货号 TMAB-01860 别名 Toll-like receptor 8, TLR8, CD288

Anti-TLR8 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 TLR8。Anti-TLR8 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P,WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-TLR8 Polyclonal Antibody is a Rabbit antibody targeting TLR8. Anti-TLR8 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
别名Toll-like receptor 8, TLR8, CD288
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Dog,Pig,Horse)
验证活性
1. Paraformaldehyde-fixed, paraffin embedded (mouse brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (TLR8) Polyclonal Antibody, Unconjugated (TMAB-01860) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
2. Paraformaldehyde-fixed, paraffin embedded (rat spleen tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (TLR8) Polyclonal Antibody, Unconjugated (TMAB-01860) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
3. Paraformaldehyde-fixed, paraffin embedded (human tonsil tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (TLR8) Polyclonal Antibody, Unconjugated (TMAB-01860) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
4. Sample:
Lane 1: Mouse Raw264.7 cell lysates
Lane 2: Human MDA-MB-231 cell lysates
Primary: Anti-TLR8 (TMAB-01860) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 117 kDa
Observed band size: 135 kDa
verifiedActivityverifiedActivityverifiedActivityverifiedActivity
应用IFIHC-FrIHC-PWB
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane.
组织特异性Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景The Toll-like Receptors (TLR) are a family of human receptors that share homology with the Drosophila Toll Receptors, which are involved in mediating dorsoventral polarization in developing Drosophila embryos and participate in host immunity. The TLR family members are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transductions. TLRs are type I transmembrane receptors that contain an extracellular domain consisting of several leucine-rich regions and a single cytoplasmic Toll/IL-1R like domain. Three TLR family members, TLR7, TLR8 and TLR9, belong to a subfamily of TLRs which are differentially expressed. TLR7 is expressed in lung, placenta and spleen. TLR8 is expressed in lung and peripheral blood leukocytes, and TLR9 is predominantly expressed in spleen, lymph nodes, bone marrow and peripheral blood leukocytes. TLR7, TLR8 and TLR9 stimulate the NFkB signaling pathway, suggesting that they play a role in the immune response.
抗原信息
免疫原
KLH conjugated synthetic peptide: human TLR 8
抗原种属
Human
基因名称
TLR8
基因ID
51311
蛋白名称
Toll-like receptor 8
Uniprot ID
Q9NR97
研究领域
Receptors,Macrophage / Inflamm.,TLR Signaling,Defensin
功能
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
化学信息
分子量Theoretical: 117 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

计算器

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关键词

Toll-like receptor8TLR 8CD 288
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