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Anti-TIE2 Antibody (1E654) 是一种 Mouse 抗体,靶向 TIE2。Anti-TIE2 Antibody (1E654) 可用于 FCM。
Anti-TIE2 Antibody (1E654) 是一种 Mouse 抗体,靶向 TIE2。Anti-TIE2 Antibody (1E654) 可用于 FCM。
产品描述 | Anti-TIE2 Antibody (1E654) is a Mouse antibody targeting TIE2. Anti-TIE2 Antibody (1E654) can be used in FCM. |
Ig Type | Monoclonal Mouse IgG1 |
克隆号 | 1E654 |
交叉反应 | Human |
验证活性 | Flow cytometric analysis of Human TIE2(CD202b) expression on HUVEC cells. Cells were stained with purified anti-Human TIE2(CD202b), then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
应用 | FCM |
推荐剂量 | FCM: 0.5-2 μg/Test |
抗体种类 | Monoclonal |
宿主来源 | Mouse |
构建方式 | This product is a recombinant monoclonal antibody expressed from HEK293 cells. |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature. |
偶联 | Unconjugated |
其他可选修饰符 | APC/FITC/PE |
可提供抗体种类 | 4 |
免疫原 | Recombinant Human TIE2 Protein (TMPY-01064) |
抗原种属 | Human |
研究领域 | Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets, Hemangioblast Markers |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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