Anti-LATS1 Polyclonal Antibody is a Rabbit antibody targeting LATS1. Anti-LATS1 Polyclonal Antibody can be used in ICC/IF.

IgG

Human (predicted:Mouse,Rat,Chicken,Pig,Cow,Horse,Rabbit)

Hela cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum) at 37°C for 20 min; Antibody incubation with (LATS1) polyclonal Antibody, Unconjugated (TMAB-01050) 1:25, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue) was used to stain the cell nucleus.

ICC/IF: 1:25

Polyclonal

KLH conjugated synthetic peptide: human LATS1

Human

LATS1

Serine/threonine-protein kinase LATS1

Tumor suppressors,Kinases,Cytokinesis,Cdk Regulators

Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor.