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Anti-IL-3R alpha/CD123 Antibody (5A691)
还可以产品编号 TMAY-00943
Anti-IL-3R alpha/CD123 Antibody (5A691) 是一种 Rabbit 抗体，靶向 IL-3R alpha/CD123。Anti-IL-3R alpha/CD123 Antibody (5A691) 可用于 ELISA,ELISA(Det)。
Anti-IL-3R alpha/CD123 Antibody (5A691)
Anti-IL-3R alpha/CD123 Antibody (5A691)
还可以产品编号 TMAY-00943
Anti-IL-3R alpha/CD123 Antibody (5A691) 是一种 Rabbit 抗体，靶向 IL-3R alpha/CD123。Anti-IL-3R alpha/CD123 Antibody (5A691) 可用于 ELISA,ELISA(Det)。
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| 产品描述 | Anti-IL-3R alpha/CD123 Antibody (5A691) is a Rabbit antibody targeting IL-3R alpha/CD123. Anti-IL-3R alpha/CD123 Antibody (5A691) can be used in ELISA,ELISA(Det). |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 5A691 |
| 交叉反应 | Human |
| 应用 | ELISA,ELISA(Det) |
| 推荐剂量 | ELISA: 1:5000-1:10000; ELISA(Det): 1:1000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human IL3RA / CD123 (rh L3RA; TMPY-01410; NP_002174.1; Met 1-Arg 305). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 5 subfamily. The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. The WSXWS motif of IL3RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box one motif of IL3RA is required for JAK interaction and/or activation. IL3RA represents a unique marker for primitive leukemic stem cells. Targeting of IL3RA may be a promising strategy for the preferential ablation of AML cells. Aberrant IL3RA expression is a good marker for monitoring of minimal residual disease. IL3RA is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recent studies have shown that interleukin-3 receptor alpha (CD123) is highly expressed on leukemia stem cells of patients with acute myeloid leukemia, and is correlated with tumor load and poor prognosis. CD123 was highly expressed in the bone marrow of the patients with myelodysplastic syndrome (MDS), significantly correlated with the proportion of bone marrow blasts, and thus might be the marker of MDS malignant clone. IL3RA is also a useful new marker for distinguishing B-cell disorders with circulating villous lymphocytes as its expression is characteristic of typical hairy cell leukemia (HCL) with high sensitivity and specificity. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human IL3RA protein (TMPY-01410) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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