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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-GDNF Polyclonal Antibody 2

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货号 TMAB-00761

Anti-GDNF Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 GDNF。Anti-GDNF Polyclonal Antibody 2 可用于 IF,IHC-Fr,IHC-P,WB。

Anti-GDNF Polyclonal Antibody 2

Anti-GDNF Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-00761

Anti-GDNF Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 GDNF。Anti-GDNF Polyclonal Antibody 2 可用于 IF,IHC-Fr,IHC-P,WB。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-GDNF Polyclonal Antibody 2 is a Rabbit antibody targeting GDNF. Anti-GDNF Polyclonal Antibody 2 can be used in IF,IHC-Fr,IHC-P,WB.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse,Sheep)
验证活性
1. Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (GDNF) Polyclonal Antibody, Unconjugated (TMAB-00761) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
2. Sample:
Cerebrum (Rat) Lysate at 40 μg
Cerebellum (Rat) Lysate at 40 μg
Primary: Anti-GDNF  (TMAB-00761) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 15 kDa
Observed band size: 20 kDa
3. Sample:
Cerebrum (Mouse) Lysate at 40 μg
Primary: Anti-GDNF  (TMAB-00761) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 15 kDa
Observed band size: 20 kDa
4. Sample:
HepG2 (Human) Cell Lysate at 30 μg
Primary: Anti-GDNF (TMAB-00761) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 15 kDa
Observed band size: 19 kDa
verifiedActivityverifiedActivityverifiedActivityverifiedActivity
应用IFIHC-FrIHC-PWB
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Secreted.
组织特异性In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景Neurobiology. Neurotrophins. Neuroscience. This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease.
抗原信息
免疫原
KLH conjugated synthetic peptide: human GDNF
抗原种属
Human
基因名称
GDNF
基因ID
2668
蛋白名称
Glial cell line-derived neurotrophic factor
Uniprot ID
P39905
研究领域
Kidney development,Neurotrophins,Amyotrophic lateral sclerosis,Parkinson's disease
功能
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
化学信息
分子量Theoretical: 15 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

计算器

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关键词

hGDNFGlial cell line-derived neurotrophic factorGDNFATFAstrocyte-derived trophic factor (ATF)
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