atf

ATF3 inducer 1 是一种高效 ATF3 诱导剂，具有降脂特性和抗高血糖活性，能减轻 HFD 诱导的葡萄糖耐量异常和胰岛素抵抗，缓解 HFD 引发的肝脏脂肪变性，可用于研究肥胖。

ATF4-IN-1 (Compound 21) 作为一种ATF4抑制剂，能够有效抑制Thapsigargin激活的HEK-293T细胞中的ATF4表达，其IC50为32.43 nM。此外，ATF4-IN-1的抑制活性优于ISRIB，并在HEK-293T细胞上展示出较低的细胞毒性（IC50为96 μM）。因其这些特性，ATF4-IN-1常被用于神经退行性疾病的研究。

ATF4-IN-2 (Compound 29)，具有47.71 nM的IC50值，是一种有效的ATF4抑制剂，常用于神经退行性疾病的研究。

SSM3 tetraTFA hydrate为有效的furin抑制剂，具有54 nM的EC50和12 nM的Ki。该化合物可有效阻断furin依赖的炭疽毒素保护antigen-83在细胞表面的处理。

Parasin I是来自鲶鱼(P. asotus)组蛋白H2A N端区域的一种抗微生物肽片段，参与宿主防御。它通过在受伤P. asotus的皮肤黏膜中的cathepsin D从组蛋白H2A形成。Parasin I对多种革兰氏阳性和阴性细菌以及真菌具有活性（MICs分别为1-2, 1-4, 和1-2 µg/ml）。

Biotin-TEG-ATFBA 作为点击化学试剂,具备全氟苯基叠氮基团.该化合物在光解后生成高度稳定的氮烯中间体,可通过中等至良好的产率进行插入和加成反应(非分子间重排).

Tunicamycin 是一种抗生素的混合物，通过阻断 GlcNAc 磷酸转移酶 (GPT)，抑制 N-连接糖基化。Tunicamycin 具有抗肿瘤活性，还具有抗细菌、抗真菌和抗病毒活性。

Cindunistat (free base) 是一种可口服的选择性 iNOS 抑制剂，可用于研究关节炎。

Cecropin A TFA is an antimicrobial polypeptide isolated from Hyalaphora cecropia pupae with anti-inflammatory, anti-bacterial, and anti-cancer activity.

Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).

FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.

AA147 (ATF6-activator-147) 是小分子内质网蛋白稳态调节剂，能够选择性激活未折叠蛋白反应的 ATF6臂。

(±)-H3RESCA-TFP is a tetrafluorophenyl ester derivative of restrained complexing agent (RESCA).

c(avb6)-DOTA TFA 是一种通过将αvβ6整合素选择性肽环与 DOTA 螯合剂结合制成的偶联物。该偶联物的 Lu (III) 配合物对αvβ6整合素具有高亲和力 (IC50=0.8 nM)，适用于肿瘤的诊断。

3,4-DHMA (3,4-Dihydroxymethamphetamine) TFA 是 3,4-MDMA 的活性代谢产物。

Tubastatin A is a potent HDAC6 inhibitor with IC50 of 15 nM.

Ianthelliformisamine A TFA, an antibiotic enhancer, is used to against resistant Gram-negative bacteria.

Bac2A TFA is an antimicrobial and immunomodulatory peptide derived from bactenecin. Notably, Bac2A TFA exhibits high efficacy in combating fungal pathogens.

Pirepemat (IRL752) fumarate 可用于研究帕金森病。Pireemat fumarate 是一种偏向皮质的儿茶酚胺传递剂和认知促进剂。

Ivaltinostat (CG-200745) formic 是一种口服具有活力的泛 HDAC 抑制剂，具有异羟肟酸部分，能够在催化袋底部结合锌。Ivaltinostat formic 对组蛋白 H3 和微管蛋白的脱乙酰作用具有抑制效果。Ivaltinostat formic 能够促使 p53 的积累，诱导 p53 依赖性反式激活，并提高 MDM2 和 p21 (Waf1/Cip1) 蛋白的表达。Ivaltinostat formic 增加 Gemcitabine 耐药细胞对 Gemcitabine 和 5-Fluorouracil (5-FU) 的敏感性。Ivaltinostat formic 诱导凋亡，并具有抗肿瘤效果。

GSK621 是一种特异性AMPK 激动剂，对 AML 细胞系的IC50值为13-30 μM。它可诱导自噬和凋亡，还可诱导eiF2α磷酸化。

Camostat, also known as FOY 305, is a serine protease inhibitor. Camostat is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease or pancreatitis. It is an inhibitor of the enzyme transmembrane protease, serine 2 (TMPRSS2). Inhibition of TMPRSS2 partially blocked infection by SARS-CoV and Human coronavirus NL63 in HeLa cell cultures. In vitro study showed that camostat significantly reduces the infection of Calu-3 lung cells by SARS-CoV-2, the virus responsible for COVID-19.

Elenbecestat,also known as E2609 is a BACE1 inhibitor. By inhibiting BACE, a key enzyme in the production of Aβ peptides, E2609 decreases the formation of these peptides which can aggregate into toxic oligomers and protofibrils and eventually form amyloid plaques in the brain. Elenbecestat has been shown to reduce Aβ levels in cerebrospinal fluid, was investigated in two global phase 3 studies in early AD.

Lys-CoA TFA为选择性p300组蛋白乙酰转移酶(HAT)抑制剂，IC50值介于50-500 nM。其对p300的选择性超过PCAF 100倍，PCAF的IC50值为200 μM。此外，Lys-CoA TFA能够抑制依赖p300-HAT活性的转录激活。