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顶部生物活性储存和溶解信息计算器

Anti-FGFR3 Antibody (6L907)

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Anti-FGFR3 Antibody (6L907)
产品编号 TMAH-00435
别名 JTK4, HSFGFR3EX, FGFR3, FGFR2 α(IIIb), FGF R3, EC 2.7.10, CEK2, CEK, CD333, ACH

Anti-FGFR3 Antibody (6L907) 是一种抗体，靶向 FGFR3。Anti-FGFR3 Antibody (6L907) 可用于 ELISA, FCM。

Anti-FGFR3 Antibody (6L907)

Anti-FGFR3 Antibody (6L907)

Rating icon 还可以
Anti-FGFR3 Antibody (6L907)
产品编号 TMAH-00435 别名 JTK4, HSFGFR3EX, FGFR3, FGFR2 α(IIIb), FGF R3, EC 2.7.10, CEK2, CEK, CD333, ACH

Anti-FGFR3 Antibody (6L907) 是一种抗体，靶向 FGFR3。Anti-FGFR3 Antibody (6L907) 可用于 ELISA, FCM。

规格价格库存数量
50 μL
¥ 1,305
5日内发货
100 μL
¥ 2,185
5日内发货
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生物活性
产品描述
Anti-FGFR3 Antibody (6L907) is an antibody targeting FGFR3. Anti-FGFR3 Antibody (6L907) can be used in ELISA, FCM.
别名JTK4, HSFGFR3EX, FGFR3, FGFR2 α(IIIb), FGF R3, EC 2.7.10, CEK2, CEK, CD333, ACH
Ig Type
hIgG1
克隆号
6L907
交叉反应
Human
验证活性
Overlay Peak curve showing MCF7 cells stained with TMAH-00435 (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4°C.Control antibody (green line) was human IgG (1ug/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed.
应用
ELISA
FCM
推荐剂量
FCM:1:50-1:200.
抗体种类
Monoclonal
亚细胞定位[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum. Note=The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
研究背景Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human FGFR3 Protein
抗原种属
Human
基因ID
2261
Uniprot ID
P22607
研究领域
Cancer, Cardiovascular, Signal transduction, Stem cells
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

JTK-4JTK 4FGFR-3FGFR 3CEK-2CEK 2CD-333CD 333

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