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Anti-FGFR1 Polyclonal Antibody
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还可以产品编号 TMAB-00674
别名 N-sam, FLT-2, FGFR1 β (IIIc), FGFR-1, CD331, bFGF-R-1, BFGFR
Anti-FGFR1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FGFR1。Anti-FGFR1 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P,WB。
Anti-FGFR1 Polyclonal Antibody
Anti-FGFR1 Polyclonal Antibody
一键复制产品信息 还可以产品编号 TMAB-00674 别名 N-sam, FLT-2, FGFR1 β (IIIc), FGFR-1, CD331, bFGF-R-1, BFGFR
Anti-FGFR1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 FGFR1。Anti-FGFR1 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P,WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,165 | 5日内发货 | |
| 100 μL | ¥ 1,970 | 5日内发货 | |
| 200 μL | ¥ 2,790 | 5日内发货 |
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| 产品描述 | Anti-FGFR1 Polyclonal Antibody is a Rabbit antibody targeting FGFR1. Anti-FGFR1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB. |
| 别名 | N-sam, FLT-2, FGFR1 β (IIIc), FGFR-1, CD331, bFGF-R-1, BFGFR |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat,Cow (predicted:Chicken,Dog) |
| 验证活性 | 1. Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (FGFR1) Polyclonal Antibody, Unconjugated (TMAB-00674) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining. 2. Sample: MCF-7 (Human) Cell Lysate at 30 μg Primary: Anti-CD331 (TMAB-00674) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 88 kDa Observed band size: 130 kDa 3. Paraformaldehyde-fixed, paraffin embedded (human laryngeal carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (FGFR1) Polyclonal Antibody, Unconjugated (TMAB-00674) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining. 4. Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (FGFR1) Polyclonal Antibody, Unconjugated (TMAB-00674) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining. 5. Paraformaldehyde-fixed, paraffin embedded (human meningioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (FGFR1) Polyclonal Antibody, Unconjugated (TMAB-00674) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.      |
| 应用 | IFIHC-FrIHC-PWB |
| 推荐剂量 | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. |
| 组织特异性 | Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 研究背景 | Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma. |
| 免疫原 | KLH conjugated synthetic peptide: human BFGFR |
| 抗原种属 | Human |
| 基因名称 | FGFR1 |
| 基因ID | |
| 蛋白名称 | Fibroblast growth factor receptor 1 |
| Uniprot ID | |
| 研究领域 | Receptor Tyrosine Kinases,FGF,Neurogenesis,SARS Coronavirus,FGF Receptors,FGF |
| 功能 | Receptor for fibroblast growth factors FGF2 and FGF1. Receptor for FGF23 in the presence of KL (By similarity). Promotes mitogenesis in response to fibroblast growth factors. Activates PLCG1. |
| 分子量 | Theoretical: 88 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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