Name: Anti-CD19 Antibody
Brand: TargetMol
SKU: T9901A-1348
Rating: 4.5 (1 reviews)

生物活性

产品描述	Anti-CD19 Antibody (Tafasitamab) is an Fc-engineered humanized monoclonal antibody that specifically targets the CD19 antigen on B lymphocytes. The compound mediates potent antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) by enhanced binding to Fcgamma receptors on effector cells, thereby directly inducing cell death and depleting malignant B cells. It serves as a pharmacological tool for investigating diffuse large B-cell lymphoma (DLBCL) and other B-cell malignancies.
体外活性	在利用淋巴瘤细胞系（Raji, Ramos）进行的细胞毒性实验中，Anti-CD19 Antibody 表现出优于非工程化抗体的效力，介导了强效的 ADCC (EC50: 0.9-4.3 pM) 和 ADCP 作用 [1]。
体内活性	在 Raji 淋巴瘤异种移植模型中，通过全身给药方式给予 Anti-CD19 Antibody，实验结果显示其引起了剂量依赖性的肿瘤消退，并显著延长了生存期 [1]。
别名	抗CD19抗体
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P15391
靶点	CD19

储存&溶解度

存储

Anti-CD19 Antibody