act-2

ACT-209905 is an agonist of S1P1 receptor.

ACT-281959, a prodrug of ACT-246475, is a novel potent and selective P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel. ACT-281959 showed antithrombotic efficacy after oral administration in the rat ferric chloride model. ACT-281959 entered clinical studies in healthy volunteers.

ACT-280778 is a potent L T calcium channel blocker.

Gallamine is an allosteric antagonist at muscarinic M2 acetylcholine receptors and an inhibitor of acetylcholinesterase.

GCC-4401C free base is a factor Xa inhibitor similar to rivaroxaban that is currently under development for venous thromboembolic disease (VTE).

CHS-828 nicotinate is a CHS-828 salt with Nicotinic acid.. CHS-828 also known as GMX-1778, is a potent and selective NAMPT inhibitor. CHS-828 inhibits cellular synthesis of NAD. CHS 828 kill tumour cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome. CHS 828 has shown promising anticancer activity in experimental tumor models and primary cultures of cancer cells from patients. CHS 828 showed a synergistic effect with melphalan in 67%, doxorubicin in 47%, etoposide in 38% and Ara-C in 14% of AML samples.

Selexipag (ACT-293987) 是前列环素受体激动剂，可引起肺血管舒张，用于治疗肺动脉高压。

3-MATIDA 是一种有效的 mGluR-1 拮抗剂（IC50：6.3 μM，大鼠 mGluR-1a）。显示出 ≥ 40 倍于其他受体的选择性：mGluR-5、mGluR-2、mGluR-4 (mGluR-4a) (IC50 > 300 μM)、NMDA 和 GluR (AMPA) (IC50 = 250 μM)。 3-MATIDA 在体外培养的鼠皮质细胞和大鼠海马切片培养物中充当神经保护剂。

RO5263397是一种 TAAR1特异性激动剂，具有口服活性，被用于抗抑郁研究。它还被发现作为环氧化酶-2 (COX-2)的抑制剂，参与前列腺素的合成。

MFCD01917484 (ETHYL 2-AMINO-4-(4-METHOXYPHENYL)-3-THIOPHENECARBOXYLATE)是一种噻吩的衍生物，它具有多种性质，包括作为配体、催化剂和光敏剂的能力。它已被用作生化和生理研究以及药物发现和开发的模型化合物。

5-Methyl-2'-deoxycytidine (5MedCyd) 是嘧啶核苷，当掺入到单链 DNA 中时，可以顺式作用以从头发出信号。

Berberine (Umbellatine) 属于生物碱类天然产物，可以激活 AMPK、抑制 DNA 拓扑异构酶、诱导 ROS 生成。Berberine 具有抗肿瘤、抗菌、降血糖、降血脂等生物学活性。

AZD4547 是FGFR 家族抑制剂，AZD4547选择性地抑制FGFR1磷酸化，并通过抑制FGFR1信号传导抑制癌细胞的增殖,并且能够作用于FGFR1 (IC50:0.2 nM)，FGFR2 (IC50:2.5 nM)，FGFR3 (IC50:1.8 nM) 和FGFR4 (IC50:165 nM)。[2]

Morroniside 通过抑制神经元凋亡和 MMP9 2 的表达从而发挥神经保护作用，可作为 db db 小鼠肝脏炎症反应和脂质代谢的调节剂。它通过抑制高血糖和氧化应激表现出对糖尿病肾损伤和人脐静脉内皮细胞的保护作用。

Vicenin 2 来源于广金钱草 (Desmodium styracifolium) 的地上部分。Vicenin 2 是一种血管紧张素转换酶 (ACE) 抑制剂，IC50=43.83 μM。

2-Hydroxymethyl-5-hydroxypyridine 是分离自S. lychnophora成熟和干燥种子的天然产物。2-Hydroxymethyl-5-hydroxypyridine 可充当激酶抑制剂。

Diacylglycerols (DAG) are generated through the hydrolysis of membrane phospholipids and function as lipid second messengers by activating protein kinase C (PKC) and modulating cell growth and apoptosis. Additionally, they act as precursors for DAG kinases in the synthesis of phosphatidic acid, a crucial lipid messenger. The compound 1-NBD-decanoyl-2-decanoyl-sn-glycerol incorporates a nitrobenzoxadiazole (NBD) fluorophore at the ω-end of its terminal decanoyl chain, using the structure of 1,2-didecanoyl-sn-glycerol as a model for diacylglycerol. This molecule is expected to exhibit excitation and emission peaks at roughly 470/541 nm, paralleling those of various NBD-labeled phospholipids. Fluorescently labeled lipids, such as this, are instrumental in exploring their interactions with proteins, their uptake by cells and liposomes, and in developing assays for lipid metabolism research.

Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10-11 M. [1] PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. [2] It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro. [3]

Momordin Ic (Momordin 1c) 是山茱萸的主要皂苷成分，通过氧化应激调控线粒体功能障碍诱导细胞凋亡，具有抗癌活性。

Ascr#2 (asc-C6-MK)是秀丽隐杆线虫中的糖苷类化合物，促进 dauer 形成。Ascr#2 在低浓度下与 ascr#3 的混合物可作为雄性引诱剂，可用于检测种群密度。

MsbA-IN-2 是一种脂多糖转运蛋白 MsbA 的有效抑制剂，能够作用于 E. coliMsbA (IC50: 2 nM)。

GRPR antagonist-2 是胃泌素释放肽受体 (GRPR) 的有效拮抗剂，对某些癌细胞具有细胞毒性（能够作用于 HGC-27 细胞 (IC50: 0.77 μM) 和 Pan02 细胞 (IC50: 2.5 μM)），表现出抗癌效果。

GPVI antagonist 2 (Compound 1) 是一种潜在的 Glycoprotein VI (GPVI) 拮抗剂，能够作用于胶原蛋白 (IC50: 0.35 μM)、CRP (IC50: 0.80 μM)、convulxin (IC50: 195.2 μM)、凝血酶 (IC50: 81.38 μM)。其中糖蛋白 VI (GPVI) 是一种血小板主要胶原受体，是有效的、安全的抗血栓研究靶点。GPVI antagonist 2 是一种很有前途的抗血小板药物。

5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) 是从黄芪中分离出的多甲氧基黄酮，具有抗炎活性，可通过直接抑制 5-LOX 发挥作用，IC50为 0.1 μM。