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Acifran

Name: Acifran
Brand: TargetMol
SKU: T22547
Price: 656 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.19%

货号 T22547Cas号 72420-38-3

别名 阿西弗兰, AY 25712

Acifran (AY 25712) 是一种 HM74A/GPR109A 和 GPR109B 激动剂，具有抗高血脂活性。

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Acifran

一键复制产品信息

很棒

纯度: 99.19%

货号 T22547 别名 阿西弗兰, AY 25712Cas号 72420-38-3

Acifran (AY 25712) 是一种 HM74A/GPR109A 和 GPR109B 激动剂，具有抗高血脂活性。

规格	价格	库存
1 mg	¥ 656	现货
5 mg	¥ 1,630	现货
10 mg	¥ 2,450	现货
25 mg	¥ 3,970	现货
50 mg	¥ 5,780	现货
100 mg	¥ 7,780	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.19%

颜色: 黄色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Acifran AI Summary

Acifran demonstrates a multifaceted bioactivity profile, showing significant lipid-lowering effects by reducing serum triglycerides levels in normal rats in a dose-dependent manner and maintaining stable liver weights. Additionally, it acts as an inhibitor of forskolin-induced cAMP generation in CHO cells, with selective inhibition at the GPR109a receptor (EC50: 1300.0 nM) over GPR109b (EC50: 4200.0 nM), and shows agonist activity with EC50 values of 160.0 nM for HCA2 and 316.0 nM for HCA3 receptors. In antiviral studies, Acifran inhibits SARS-CoV-2 induced cytotoxicity in different cell types and assays, and also displays potential activity against SARS-CoV-2 viral replication by inhibiting the 3CL-Pro protease. Furthermore, it has demonstrated inhibitory effects on human HDAC6 enzyme activity, although the inhibition percentages are minimal. This broad spectrum of bioactivities suggests its potential as a therapeutic candidate for conditions related to lipid metabolism, viral infections, and possibly other targets within these pathways..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Acifran (AY 25712) is an HM74A/GPR109A and GPR109B agonist and displays antihyperlipidemic activity.
别名	阿西弗兰, AY 25712

化学信息

分子量	218.21
分子式	C₁₂H₁₀O₄
CAS No.	72420-38-3
Smiles	CC1(OC(=CC1=O)C(O)=O)c1ccccc1
密度	1.343 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: 19.6 mg/mL (89.82 mM), Sonication is recommended.

DMSO: 19.6 mg/mL (89.82 mM), Sonication is recommended.

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5827 mL	22.9137 mL	45.8274 mL	229.1371 mL
5 mM	0.9165 mL	4.5827 mL	9.1655 mL	45.8274 mL
10 mM	0.4583 mL	2.2914 mL	4.5827 mL	22.9137 mL
20 mM	0.2291 mL	1.1457 mL	2.2914 mL	11.4569 mL
50 mM	0.0917 mL	0.4583 mL	0.9165 mL	4.5827 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。