AC265347

Name: AC265347
Brand: TargetMol
SKU: T29541
Price: 458 CNY
Availability: InStock
Rating: 5 (10 reviews)

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货号 T29541Cas号 1253901-26-6

别名 AC-265347

AC265347 是一种有效的钙敏感受体 (CaSR) 激动剂和 ago-PAM 正变构调节剂，具有抗肿瘤活性，通过诱导分化抑制神经母细胞瘤肿瘤生长。AC265347 可用于研究神经母细胞瘤。

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AC265347

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货号 T29541 别名 AC-265347Cas号 1253901-26-6

规格	价格	库存
1 mg	¥ 458	现货
5 mg	¥ 1,090	现货
10 mg	¥ 1,860	现货
25 mg	¥ 3,730	现货
50 mg	¥ 5,320	现货
100 mg	¥ 7,280	现货
500 mg	¥ 14,500	现货

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产品介绍

AC265347 AI Summary

AC265347 exhibits a wide range of bioactivities across various biological systems. It demonstrates high intrinsic clearance in human liver microsomes with a clearance rate of 396.0 mL.min^-1.g^-1. Functionally, it acts as a positive allosteric modulator of the calcium sensing receptor, showing an efficacy of 91.0% and an EC50 value of 25.12 nM in a cell-based assay. It also inhibits Plasmodium falciparum proliferation, displaying potencies that vary between 0.9 nM and 18821.2 nM across different strains of the parasite. In terms of cell viability, AC265347 has variable impacts depending on the cell type. It enhances growth rates in HEK293T cells from 0.84 to 0.99, whereas it exhibits a broader range of effects in U2OS cells, with growth rates spanning from -0.06 to 0.99. In human fibroblast cells, the compound consistently promotes cell growth, with rates ranging from 0.44 to 0.92, highlighting its potential cell-type specific bioactivities. Thermal Shift Assay results indicate that AC265347 affects the thermal stability of various protein domains differently. It decreases thermal stability in domains N44-E168 and M626-G740 (Delta TM = -2.23°C and -2.16°C respectively), suggesting protein destabilization. Conversely, it increases stability in domains E122-S403, P449-E759, and M1-S360 (Delta TM = 0.51°C, 0.21°C, and 0.76°C respectively), signifying a stabilizing effect. Furthermore, AC265347 exhibits inhibitory effects in GPCR beta-arrestin recruitment assays targeting multiple receptors including CX3CR1, AGTR1, ADGRF1, C5AR1, GLP1R, FFAR4, GPR119, ADRA2A, FPR2, GPR35, S1PR1, ADRB2, APLNR, and ADGRF1. Some assays also suggest a positive maximal effect on receptors such as GLP1R, ADRA2A, FPR2, GPR35, AGTR1, S1PR1, APLNR, and FFAR4. Overall, AC265347 demonstrates a complex interplay of stabilizing and destabilizing effects on protein structures and varied impacts on cell viability and GPCR activity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	AC265347 is a potent calcium-sensitive receptor (CaSR) agonist and ago-PAM orthosteric modulator with antitumour activity that inhibits neuroblastoma tumour growth by inducing differentiation.AC265347 can be used to study neuroblastoma.
别名	AC-265347

化学信息

分子量	283.39
分子式	C₁₇H₁₇NOS
CAS No.	1253901-26-6
Smiles	OC(C1=NC=2C=CC=CC2S1)(C3=CC=C(C=C3C)C)C
密度	no data available

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (282.3 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.64 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5287 mL	17.6435 mL	35.2871 mL	176.4353 mL
5 mM	0.7057 mL	3.5287 mL	7.0574 mL	35.2871 mL
10 mM	0.3529 mL	1.7644 mL	3.5287 mL	17.6435 mL
20 mM	0.1764 mL	0.8822 mL	1.7644 mL	8.8218 mL
50 mM	0.0706 mL	0.3529 mL	0.7057 mL	3.5287 mL
100 mM	0.0353 mL	0.1764 mL	0.3529 mL	1.7644 mL