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αC-Conotoxin PrXA为麻痹肽类神经毒素,亦是竞争性nAChR拮抗剂,对α1β1εδ(成人型)和α1β1γδ(胎儿型)nAChR的IC50值分别为1.8 nM和3.0 nM。该化合物通过与α-bungarotoxin竞争nAChR的α/δ及α/γ亚基界面,展现出对神经肌肉型nAChR的高度特异性。
αC-Conotoxin PrXA为麻痹肽类神经毒素,亦是竞争性nAChR拮抗剂,对α1β1εδ(成人型)和α1β1γδ(胎儿型)nAChR的IC50值分别为1.8 nM和3.0 nM。该化合物通过与α-bungarotoxin竞争nAChR的α/δ及α/γ亚基界面,展现出对神经肌肉型nAChR的高度特异性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | 待询 | 待询 | |
50 mg | 待询 | 待询 |
αC-Conotoxin PrXA 相关产品
产品描述 | αC-Conotoxin PrXA is a neurotoxic paralytic peptide acting as a competitive antagonist of the nicotinic acetylcholine receptor (nAChR), exhibiting inhibitory constants (IC50) of 1.8 nM for the adult α1β1εδ subtype and 3.0 nM for the fetal α1β1γδ subtype. The compound vies with α-bungarotoxin for binding sites at the α/δ and α/γ interfaces of neuromuscular nAChRs, demonstrating high selectivity[1]. |
别名 | αC-PrXA |
分子量 | 3541.06 |
分子式 | C160H247N43O44S2 |
Sequence | Thr-Tyr-Gly-Ile-Tyr-Asp-Ala-Lys-Pro-{Hyp}-Phe-Ser-Cys-Ala-Gly-Leu-Arg-Gly-Gly-Cys-Val-Leu-Pro-{Hyp}-Asn-Leu-Arg-{Hyp}-Lys-Phe-Lys-Glu-NH2 (Disulfide bridge:Cys13-Cys20) |
Sequence Short | TYGIYDAKP-{Hyp}-FSCAGLRGGCVLP-{Hyp}-NLR-{Hyp}-KFKE-NH2 (Disulfide bridge:Cys13-Cys20) |
存储 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
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