Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Propafenone hydrochloride (Arythmol8) 具有抗心律不齐的功效,可用于心房和心室性心律不齐。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
200 mg | ¥ 150 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 418 | 现货 |
产品描述 | Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias. |
体外活性 | MK 3207 exhibits significantly higher affinity for both native and recombinant human CGRP receptor, as well as rhesus monkey CGRP receptor with Ki of 24 pM, ~24 pM and 22 pM, respectively, as compared to CGRP receptors from other species, including canine and rodent (Ki values of ~10 nM). Although has affinity for AMY1 (CTR/RAMP1) receptor with a Ki value of 0.75 nM, MK 3207 displays marked selectivity for human CGRP receptor versus related human AM1 (CLR/RAMP2) receptor, AM2 (CLR/RAMP3) receptor, AMY3 (CTR/RAMP3) receptor, and CTR with Ki values of 16.5 μM, 0.156 μM, 0.128 μM and 1.9 μM, respectively. MK 3207 potently inhibits human α-CGRP-induced cAMP production in HEK293 cells stably expressing human CLR/RAMP1 with an IC50 of 0.12 nM, and maintains similar potency in the presence of 50% human serum with an IC50 of 0.17 nM, indicating that the activity of MK 3207 would not be dramatically affected by plasma protein binding in vivo. MK 3207 exhibits approximately 65-fold more potent in the human serum-shifted in vitro functional assay than telcagepant with an IC50 of 10.9 nM. [1] |
别名 | Propafenone HCl, Arythmol, SA-79 (hydrochloride), Rytmonorm, 盐酸普罗帕酮, Rythmol |
分子量 | 377.9 |
分子式 | C21H27NO3·HCl |
CAS No. | 34183-22-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 64 mg/mL (169.4 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6462 mL | 13.231 mL | 26.462 mL | 66.1551 mL |
5 mM | 0.5292 mL | 2.6462 mL | 5.2924 mL | 13.231 mL | |
10 mM | 0.2646 mL | 1.3231 mL | 2.6462 mL | 6.6155 mL | |
20 mM | 0.1323 mL | 0.6616 mL | 1.3231 mL | 3.3078 mL | |
50 mM | 0.0529 mL | 0.2646 mL | 0.5292 mL | 1.3231 mL | |
100 mM | 0.0265 mL | 0.1323 mL | 0.2646 mL | 0.6616 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Propafenone hydrochloride 34183-22-7 Membrane transporter/Ion channel Sodium Channel Propafenone HCl Arythmol SA 79 Na+ channels SA-79 (hydrochloride) Na channels Inhibitor Rytmonorm SA-79 Propafenone 盐酸普罗帕酮 SA79 inhibit Rythmol Propafenone Hydrochloride inhibitor