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Hydrocortisone acetate

Name: Hydrocortisone acetate
Brand: TargetMol
SKU: T1243
Price: 133 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.22%

货号 T1243Cas号 50-03-3

别名 醋酸氢化可的松, Hydrocortisone 21-acetate, Cortisol 21-acetate

Hydrocortisone acetate (Cortisol 21-acetate) 是皮质类固醇，能够减少轻微皮肤刺激或痔疮引起的肿胀、搔痒和疼痛。

Hydrocortisone acetate

一键复制产品信息

很棒

纯度: 99.22%

货号 T1243 别名 醋酸氢化可的松, Hydrocortisone 21-acetate, Cortisol 21-acetateCas号 50-03-3

Hydrocortisone acetate (Cortisol 21-acetate) 是皮质类固醇，能够减少轻微皮肤刺激或痔疮引起的肿胀、搔痒和疼痛。

规格	价格	库存
200 mg	¥ 133	现货
500 mg	¥ 196	待询
1 g	¥ 328	待询
1 mL x 10 mM (in DMSO)	¥ 150	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.22%

颜色: 白色

性状: Solid

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COA LCMS HNMR 产品操作手册

产品介绍

Hydrocortisone acetate AI Summary

Hydrocortisone acetate exhibits a variety of bioactivities and pharmacological properties across different assays and receptor interactions. It shows strong binding affinity to corticosteroid-binding globulin (CBG) with a log K of 7.553 and a Ki value of 28.18 nM. For glucocorticoid receptors, it has a high relative binding affinity (RBA) in liver (RBA = 10.0 at 4 hr) and moderate affinity in hepatoma tissue cells (RBA = 9.0 at 4 hr, and RBA = 8.0 at 24 hr), but lower affinity in the thymus (RBA = 3.4 at 4 hr, and RBA = 3.3 at 24 hr). The compound also demonstrates negligible binding to progestin, androgen, and mineralocorticoid receptors. Additionally, it induces Tyrosine Aminotransferase activity to 91% relative to Dexamethasone. Hydrocortisone acetate shows similar potency to fluocinolone 16,17-acetonide in human vasoconstrictor tests and comparable anti-inflammatory effects to hydrocortisone in rat granuloma assays. From a physicochemical perspective, Hydrocortisone acetate has a logP value of 2.26 (HPLC method) and 2.19 (general method), indicating moderate lipophilicity. It has a high HPLC capacity factor (log k'w = 1.93), suggesting good retention on the HPLC column, and an intrinsic aqueous solubility of logS0 = -4.34 at pH 10. In antiviral assays, Hydrocortisone acetate inhibits SARS-CoV-2-induced cytotoxicity in VERO-6 cells and shows inhibitory activity against SARS-CoV-2 3CL-Pro protease (13.7% inhibition at 20 µM). It also demonstrates moderate to high inhibition of sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells (93.94% and 91.1% inhibition, respectively, at 10 µM). In various bioactivity assays, Hydrocortisone acetate acts as an inhibitor of pathways such as AmpC Beta-Lactamase, Nrf2 signaling, Histone Lysine Methyltransferase G9a, ERG Ets/DNA interaction, and several others. Additionally, it exhibits antifungal and antibacterial activity against multiple strains, including Candida albicans, Cryptococcus neoformans, Escherichia coli, and Staphylococcus aureus MRSA, among others. Overall, Hydrocortisone acetate has potential therapeutic applications across various biological pathways and disease models due to its broad spectrum of bioactivities and moderate lipophilicity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Hydrocortisone acetate (Cortisol 21-acetate) is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.
别名	醋酸氢化可的松, Hydrocortisone 21-acetate, Cortisol 21-acetate

化学信息

分子量	404.5
分子式	C₂₃H₃₂O₆
CAS No.	50-03-3
Smiles	C[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])(CC[C@@]2(C(COC(C)=O)=O)O)[H]
密度	1.26 g/cm/3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (148.33 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 2.5 mg/mL (6.18 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4722 mL	12.3609 mL	24.7219 mL	123.6094 mL
5 mM	0.4944 mL	2.4722 mL	4.9444 mL	24.7219 mL
10 mM	0.2472 mL	1.2361 mL	2.4722 mL	12.3609 mL
20 mM	0.1236 mL	0.6180 mL	1.2361 mL	6.1805 mL
50 mM	0.0494 mL	0.2472 mL	0.4944 mL	2.4722 mL
100 mM	0.0247 mL	0.1236 mL	0.2472 mL	1.2361 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Inhibitor inhibit Hydrocortisone Acetate Hydrocortisone GlucocorticoidReceptor Glucocorticoid Receptor EndogenousMetabolite Endogenous Metabolite Cortisol AnnexinA Annexin A1 Annexin A

Hydrocortisone acetate

Hydrocortisone acetate