Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cathepsin inhibitor 1 是Cathepsin 的选择性抑制剂,能够抑制CatL(pIC50:7.9)、CatL2(pIC50:6.7)、CatS(pIC50:6.0)、CatK(pIC50:5.5)和CatB(pIC50:5.2)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 395 | 现货 | ||
5 mg | ¥ 937 | 现货 | ||
10 mg | ¥ 1,570 | 现货 | ||
25 mg | ¥ 3,190 | 现货 | ||
50 mg | ¥ 4,790 | 现货 | ||
100 mg | ¥ 6,830 | 现货 | ||
500 mg | ¥ 13,700 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,090 | 现货 |
产品描述 | Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. |
靶点活性 | Cathepsin L:7.9(pIC50), cathepsin K:5.5(pIC50), Cathepsin S:6(pIC50), Cathepsin B:5.2(pIC50), Cathepsin L2:6.7(pIC50) |
体内活性 | Ciproxifan intravenously injected at dose of 1 mg/kg decreases the H3-receptor ligand concentration in serum in Male Swiss mice, with half-times of distribution phase of 13min and elimination phase of 87 min, respectively. Ciproxifan (1 mg/kg, p.o.) rises brain t-MeHA level rapidly in Male Swiss mice, being already significantly increased after 30 min, reaching a plateau between 90 and 180 min and still remaining enhanced after 270 min. Ciproxifan leads to ED50 values of 0.23 mg/kg in cerebral cortex, 0.28 mg/kg in striatum and 0.30 mg/kg in hypothalamus in Male Wistar rats. Ciproxifan (3 mg/kg, i.p.) significantly increases choice accuracy as evaluated in the five-choice task performed using a short stimulus duration. Ciproxifan (0.15-2 mg/kg, p.o.) induces marked signs of neocortical electroencephalogram activation manifested by enhanced fast-rhythms density and an almost total waking state in cats. [1] Ciproxifan (10 mg/kg i.p.) enhances prepulse inhibition in the DBA/2 strain mice. [3] Ciproxifan (3 mg/kg i.p.) alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. [4] Ciproxifan (3 mg/kg i.p.) improves accuracy and decreased impulsivity in adult male hooded Lister rats. [5] |
分子量 | 401.89 |
分子式 | C20H24ClN5O2 |
CAS No. | 225120-65-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 74 mg/mL (184.1 mM)
Ethanol: 47 mg/mL (116.9 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 2.4882 mL | 12.4412 mL | 24.8824 mL | 62.2061 mL |
5 mM | 0.4976 mL | 2.4882 mL | 4.9765 mL | 12.4412 mL | |
10 mM | 0.2488 mL | 1.2441 mL | 2.4882 mL | 6.2206 mL | |
20 mM | 0.1244 mL | 0.6221 mL | 1.2441 mL | 3.1103 mL | |
50 mM | 0.0498 mL | 0.2488 mL | 0.4976 mL | 1.2441 mL | |
100 mM | 0.0249 mL | 0.1244 mL | 0.2488 mL | 0.6221 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cathepsin Inhibitor 1 225120-65-0 Proteases/Proteasome Cysteine Protease Cathepsin Inhibitor CatK CatB CatL Cathepsin inhibitor-1 inhibit CatL2 Cathepsin inhibitor1 CatS inhibitor