Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Abarelix (PPI 149) 是一种促性腺激素释放激素 (GnRH) 拮抗剂,用于前列腺癌研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 497 | 现货 | ||
2 mg | ¥ 729 | 现货 | ||
5 mg | ¥ 1,230 | 现货 | ||
10 mg | ¥ 1,980 | 现货 | ||
25 mg | ¥ 3,370 | 现货 | ||
50 mg | ¥ 4,880 | 现货 | ||
100 mg | ¥ 6,990 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,170 | 现货 |
产品描述 | Abarelix (PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, which is used for prostate cancer treatment. |
体外活性 | Abarelix (30 and 300 µg/mL) causes significantly increased histamine release[1]. Abarelix demonstrates to promptly and substantially reduce follicle-stimulating hormone levels to lower than LHRH agonist. Abarelix is the first GnRH antagonist to be developed which can produce rapid and sustained decreases in testosterone to castrate levels without the need for co-administration of an antiandrogen, and with a very low complication rate in the short term[2]. Abarelix does not cause a surge in serum testosterone that can precipitate a flare phenomenon or worsening of disease, particularly dangerous for patients with metastatic, symptomatic disease, and produces medical castration more quickly[3]. |
别名 | R3827, 阿巴瑞克, PPI 149 |
分子量 | 1416.06 |
分子式 | C72H95ClN14O14 |
CAS No. | 183552-38-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 14.2 mg/mL (10.03 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 0.7062 mL | 3.5309 mL | 7.0618 mL | 17.6546 mL |
5 mM | 0.1412 mL | 0.7062 mL | 1.4124 mL | 3.5309 mL | |
10 mM | 0.0706 mL | 0.3531 mL | 0.7062 mL | 1.7655 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Abarelix 183552-38-7 GPCR/G Protein GNRH Receptor GNRHR R 3827 GnRH Receptor R3827 Gonadotropin releasing hormone receptor 阿巴瑞克 PPI-149 inhibit PPI 149 R-3827 Inhibitor PPI149 inhibitor