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20-HETE 促进癌症中的细胞增殖和迁移,通过激活蛋白激酶 C 通路以增加 FBXO10 的表达,可用于研究前列腺肿瘤和心脏肥大。
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20-HETE 促进癌症中的细胞增殖和迁移,通过激活蛋白激酶 C 通路以增加 FBXO10 的表达,可用于研究前列腺肿瘤和心脏肥大。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
100 μg (312.04 μM * 1 mL in Ethanol) | ¥ 3,230 | 现货 | |
100 μg (312.04 μM * 1 mL in Ethanol) | ¥ 3,230 | 现货 | |
1 mg (312.04 μM * 10 mL in Ethanol) | ¥ 7,490 | 现货 | |
1 mg (312.04 μM * 10 mL in Ethanol) | ¥ 7,490 | 现货 | |
5 mg (312.04 μM * 50 mL in Ethanol) | ¥ 16,000 | 现货 | |
5 mg (312.04 μM * 50 mL in Ethanol) | ¥ 16,000 | 现货 |
产品描述 | 20-HETE promotes cell proliferation and migration in cancer and can be used to study prostate tumors and cardiac hypertrophy by activating the protein kinase C pathway to increase FBXO10 expression.20-HETE promotes cell proliferation and migration in cancer and can be used to study prostate tumors and cardiac hypertrophy by activating the protein kinase C pathway. |
体外活性 | 17-ODYA(1 μM)增加了大电导 Ca(2+)激活的 K+ 通道的活性,并且这种效应被 20-HETE 逆转(10 nM)。20-HETE(1-1000nM)将大鼠分离灌注的小肾动脉的直径减小约15%,TEA(1mM)阻断血管收缩剂对 20-HETE 的反应(100nM)[1]。 |
体内活性 | 20-HETE 有助于 DHT 诱导的血管重塑,与血压升高无关[2]。 |
别名 | 20-hydroxy Arachidonic Acid |
分子量 | 320.47 |
分子式 | C20H32O3 |
CAS No. | 79551-86-3 |
存储 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
溶解度信息 | DMSO: 2 mg/mL (6.24 mM), Sonication is recommended. Ethanol: 5 mg/mL (15.60 mM), Sonication is recommended. | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
DMSO/Ethanol
Ethanol
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