Name: 2-Propylpent-4-ynoic acid
Brand: TargetMol
SKU: T218992
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

10-14周

50 mg

待询

10-14周

生物活性

产品描述	2-Propylpent-4-ynoic acid (4-yn-VPA) is identified as an HDAC inhibitor, with an IC50 value of 0.5 mM against human HDAC. It induces P-glycoprotein function and exhibits teratogenic effects, fetal growth inhibition, and neurotoxicity. The compound demonstrates significant stereospecific teratogenic effects, with the S-enantiomer being more teratogenic than the R-enantiomer and other analogs, although its neurotoxicity is not associated with stereochemistry. This compound has been utilized in studies related to the pathogenesis of colon cancer and neural tube defects, such as exencephaly.
体外活性	2-Propylpent-4-ynoic acid (4-yn-VPA) 在 1 mM 处理 5 d 条件下可诱导人结肠腺癌 SW620 细胞中 P-gp 功能，其对 HeLa 细胞核提取物的 HDAC 抑制活性 IC 50 为 0.5 mM。
体内活性	在诱导小鼠露脑畸形方面，2-Propylpent-4-ynoic acid (4-yn-VPA) 的 S-(-)-4-yn-VPA 异构体于妊娠第 8 天经腹腔注射单次给药 (0.40-1.05 mmol/kg) 的效力较 R(+)-4-yn-VPA 异构体 (3-6 mmol/kg；腹腔注射；妊娠第 8 天；单次) 高 7.5 倍；两者的 ED 50 分别为 0.83 mmol/kg 和 6.19 mmol/kg。
别名	4-yn-VPA

化学信息

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

2-Propylpent-4-ynoic acid