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顶部相关产品产品介绍化学信息储存和溶解信息计算器

17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α

Synonyms: 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
货号 T37948Cas号 294856-01-2 一键复制产品信息
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A number of 17-phenyl trinor prostaglandin F2α(17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.1,2,3Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.417-trifluoromethylphenyl-13,14-dihydro trinor PGF2αbears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2αwould act very much like the free acid of latanoprost.

17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α

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货号 T37948Cas号 294856-01-2

别名 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α

A number of 17-phenyl trinor prostaglandin F2α(17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.1,2,3Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.417-trifluoromethylphenyl-13,14-dihydro trinor PGF2αbears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2αwould act very much like the free acid of latanoprost.

17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
规格价格库存数量
1 mg
¥ 1,760
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5 mg
¥ 7,780
35日内发货
10 mg
¥ 13,800
35日内发货
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产品介绍

生物活性
产品描述
A number of 17-phenyl trinor prostaglandin F2α(17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.1,2,3Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.417-trifluoromethylphenyl-13,14-dihydro trinor PGF2αbears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2αwould act very much like the free acid of latanoprost.
别名
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
化学信息
分子量458.518
分子式C24H33F3O5
CAS No.294856-01-2
SmilesO[C@H](CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O)CCc1cccc(c1)C(F)(F)F
密度no data available
储存&溶解度
存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息
DMF: 30 mg/mL (65.43 mM), Sonication is recommended.
Ethanol: 50 mg/mL (109.05 mM), Sonication is recommended.
PBS (pH 7.2): 1 mg/mL (2.18 mM), Sonication is recommended.
DMSO: 25 mg/mL (54.52 mM), Sonication is recommended.
溶液配制表
PBS (pH 7.2)/DMSO/DMF/Ethanol
1mg5mg10mg50mg
1 mM2.1809 mL10.9047 mL21.8094 mL109.0470 mL
DMSO/DMF/Ethanol
1mg5mg10mg50mg
5 mM0.4362 mL2.1809 mL4.3619 mL21.8094 mL
10 mM0.2181 mL1.0905 mL2.1809 mL10.9047 mL
20 mM0.1090 mL0.5452 mL1.0905 mL5.4523 mL
50 mM0.0436 mL0.2181 mL0.4362 mL2.1809 mL
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

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