Name: α-Conotoxin Vc1.1
Brand: TargetMol
SKU: T73894L
Rating: 4.5 (1 reviews)

生物活性

产品描述	α-Conotoxin Vc1.1 are potent, short peptide neurotoxins derived from the venom of marine cone snails that selectively and competitively block nicotinic acetylcholine receptors (nAChRs) in the nervous system, serving as highly specific molecular probes to dissect nAChR subtype function and as promising drug discovery leads for pain management, oncology research, and neurological disorder studies by precisely modulating neurotransmission, inhibiting nerve signal propagation, and inducing controlled paralysis in experimental systems.
靶点活性	nAChR:~100 nM
体外活性	α-Conotoxin Vc1.1 能以纳摩尔级别的 IC₅₀（约 100 nM 或更低）有效抑制尼古丁诱导的儿茶酚胺释放，从而证实了其对胆碱能信号传递具有显著的阻断作用。
体内活性	在大鼠隐神经模型中，局部灌流 α-Conotoxin α-Conotoxin Vc1.1 显著抑制了由感觉 C-纤维电刺激引起的神经源性炎症（具体表现为血管扩张和血浆外渗）。
别名	α-芋螺毒素 Vc1.1

化学信息

分子量	1811.01
分子式	C₇₁H₁₀₇N₂₃O₂₅S₄
CAS No.	913961-64-5
Smiles	C([C@H](CC1=CN=CN1)NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]3N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CS)=O)CS)=O)CO)=O)CC(O)=O)=O)CCC3)CCCNC(=N)N)=O)CS)=O)CC(N)=O)=O)=O)CC(O)=O)=O)(=O)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CS)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CCC4
密度	no data available
Sequence	Glycyl-L-cysteinyl-L-cysteinyl-L-seryl-L-α-aspartyl-L-prolyl-L-arginyl-L-cysteinyl-L-asparaginyl-L-tyrosyl-L-α-aspartyl-L-histidyl-L-prolyl-L-α-glutamyl-L-isoleucyl-L-cysteinamide

储存&溶解度

存储

α-Conotoxin Vc1.1