zanamivir

Zanamivir (GG167) 是神经氨酸酶抑制剂，对于流感病毒 A 和B 的IC50值分别为0.95 nM 和2.7 nM。

Zanamivir-13C,15N2is intended for use as an internal standard for the quantification of zanamivir by GC- or LC-MS. Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles.1It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC50values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC50values ranging from 0.6 to 7.9 nMin vitro. Intranasal zanamivir administration at 0.4 mg kg twice daily reduces mortality and viral titers in lung homogenates of mice infected with influenza. 1.Elliott, M.Zanamivir: From drug design to the clinicPhilos. Trans. R. Soc. Lond. B Biol Sci.356(1416)1885-1893(2001)

Zanamivir-cholesterol conjugate is an extended-duration neuraminidase inhibitor highly effective against drug-resistant influenza strains.

Zanamivir amine是一种抗病毒化合物，主要用于抑制流感病毒。作为神经氨酸酶抑制剂，它通过干扰病毒的复制过程，有效减少病毒载量，从而限制病毒的增殖。在临床上，Zanamivir amine常用于预防和治疗流感感染。

Zanamivir hydrate is neuraminidase inhibitors. It is used worldwide for the treatment and prophylaxis of influenza caused by influenza A and B viruses.