way-100135

WAY-100135 dihydrochloride is a potent and selective antagonist of both presynaptic and postsynaptic 5-HT 1A receptors, exhibiting an IC 50 value of 34 nM specifically at the rat hippocampal 5-HT 1A receptor. This compound displays promising antipsychotic effects.

Way 100135 is a serotonergic drug of the phenylpiperazine family which is used in scientific research. It acts as a potent 5-HT1A receptor antagonist and a partial agonist of the 5-HT1D receptor, and to a much lesser extent, of the 5-HT1B receptor.