vsig 9

TIGIT Protein, Human, Recombinant (aa 22-141, His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 14.51 kDa and the accession number is NP_776160.2.

T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113 (PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: BLI、ELISA

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: ELISA

Expression system: HEK293 Cells
Length: 22-141, Extracellular Domain
Activity: ELISA

Expression system: HEK293 Cells
Length: 22-141, Extracellular Domain
Activity: SPR、BLI、Octet RED、ELISA

TIGIT Protein, Human, Recombinant (HEK293, His) is expressed in HEK293 Cells+J15. The accession number is Q495A1.