urdamycin a

Urdamycin A is a bacterial metabolite originally isolated fromS. fradiaethat has antibacterial and anticancer activities.1,2It is active against a variety of Gram-positive and Gram-negative bacteria, includingB. subtilisand strains ofArthrobacterandStreptomyces, but not the fungusS. cerevisiae, in a disc assay when used at a concentration of 1 mg ml.2Urdamycin A is cytotoxic to L1210 and HT-29, but not A549, cancer cells (IC50s = 7.5, 5, and >10 μg ml, respectively).1

Urdamycin B是一种从Streptomyces fradiae代谢产物中提取的antibiotic，具有抑制真菌和细菌的效能。此外，该化合物对小鼠白血病细胞L1210展示出抗增殖活性，可应用于癌症及细菌、真菌感染的研究。