UBP608 is an allosteric modulator of NMDA receptor family. It selectively inhibits GluN1 GluN2A receptors with a 23-fold selectivity compared to GluN1 GluN2D receptors.
UBP714 is a derivative of the NMDA receptor negative allosteric modulator UBP608. It also enhanced NMDAR mediated field EPSPs in the CA1 region of the hippocampus. UBP714 is a novel template for the development of potent and subunit selective NMDAR potent