Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis. BGB-290 may both potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance.
Trimetoquinol HCl hydrate (Standard) is the standard substance of Trimetoquinol HCl hydrate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Trimetoquinolhydrochloride possesses differential and selective beta-adrenergic properties.