tp-3076

CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein). CH-0793076 inhibits DNA topoisomerase I (IC50: 2.3 μM).

Dihydrochlamydocinanalog-1 (compound 2) 是 Chlamydocin 的类似物，能够有效抑制组蛋白 H4 肽的去乙酰化，其 IC50 值为 30 nM。