tlr4 in c34 c2 cooh

TLR4-IN-C34-C2-COO is a linker compound that incorporates TLR4 inhibitor TLR4-IN-C34. It effectively inhibits TLR4 activity in enterocytes and macrophages. Moreover, it demonstrates a notable ability to mitigate systemic inflammation in murine models of endotoxemia and necrotizing enterocolitis.

Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH为包括TLR4抑制剂TLR4-IN-C34的连接子。该化合物通过抑制肠细胞与巨噬细胞内TLR4活性，能够减轻内毒素血症及坏死性小肠结肠炎小鼠模型中的全身性炎症。

Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH 是一种融合了TLR4-IN-C34抑制剂的连接子。这种抑制剂在阻断肠细胞与巨噬细胞内的TLR4上发挥作用，有效减轻了内毒素血症及坏死性小肠结肠炎小鼠模型中的全身性炎症现象。