thalidomide-o-cooh

Thalidomide-O-COOH (Cereblon ligand 3) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。

Thalidomide-O-amido-C3-COOH is a synthesized conjugate of an E3 ligase ligand-linker compound that combines a cereblon ligand derived from Thalidomide with a linker commonly employed in PROTAC technology.

JB300 是一种利用PROTAC技术的Aurora A高选择性降解剂（DC50=30 nM），用于肿瘤研究。JB300 由PROTAC靶蛋白配体MK-5108 (pink part)、E3连接酶配体Thalidomide-O-COOH (blue part) 及PROTAC Linker Boc-NH-PEG2-C2-NH2 (black part) 组成，其中E3泛素连接酶配体与Linker的结合物为Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc。

Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc 是一种包含 E3 连接酶配体和连接子的偶联物，结合了基于 Thalidomide 的 CEREBLON 配体和一个 PEG linker。此化合物可以用于合成 PROTAC 降解剂 JB300。

Thalidomide-O-C4-COOH is a synthetic conjugate compound, serving as an E3 ligase ligand-linker, which combines a cereblon ligand derived from Thalidomide and a linker utilized in PROTAC technology.

Thalidomide-O-C6-COOH is a synthetic conjugate comprising an E3 ligase ligand-linker, which combines the Thalidomide derived cereblon ligand with a PROTAC technology linker.

Thalidomide-O-C8-COOH，一种Thalidomide衍生的Cereblon配体，能有效募集CRBN蛋白。通过linker，Thalidomide-O-C8-COOH可与靶蛋白配体结合，构建PROTAC分子。