tcopeg8acid

TCO-PEG8-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

(R)-TCO-PEG8-acid 是一种含有 8 个 PEG 单元的ADC Linker。其 TCO 基团能够与带有 Tetrazine 基团的分子进行逆电子需求 Diels-Alder?反应 (iEDDA)。