tco peg8 amine

TCO-PEG8-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Methyltetrazine-amido-PEG8-amine Trifluoroacetate 是一种异双功能连接体，具有末端甲基四嗪，能够在无需 Cu 催化或高温的条件下与含 TCO 的化合物发生反应；其末端胺组分可与 NHS 酯进行特异高效的反应。PEG 间隔基具有增强水溶性的作用。