talarozole

(-)-Talarozole is a potent retinoic acid metabolism inhibitor.

Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid.

Talarozole (R115866) 是一种口服性全反式维甲酸代谢阻断剂，可抑制 CYP26A1 和 CYP26B1，IC50 分别为 5.4 和 0.46 nM。它用于治疗痤疮、牛皮癣和其他角化疾病。