tak-285

TAK-285 是一种新型 HER2 和 EGFR(HER1) 双重抑制剂，IC50 分别为 17 和 23 nM。它可穿过血脑屏障，有抗肿瘤活性，对 HER1 2 的选择性是 HER4 的 10 倍以上。

TAK285-IODO, similar to TAK285 in which the trifluoro group is replaced by iodo, is a novel dual erbB protein kinase inhibitor that specifically targets human epidermal growth factor receptor (EGFR) and HER2.