sstr3

BIM 23056 Acetate 是一种有效且可克服的人类重组 sst5 受体拮抗剂。

MK-4256 is an effective and selective SSTR3 antagonist (IC50s: 0.66 nM and 0.36 nM in human and mouse receptor binding assays, respectively).

BN-81,674 is a bioactive chemical.

Cortistatin-29 is a neuropeptide that is structurally similar to somatostatin-28. It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cortistatin-14 as well as other partial cleavage products. Cortistatin mRNA is expressed in the human brain and in interneurons of the rat hippocampus and cerebral cortex. Cortistatin-29 binds to somatostatin (SST) receptors with IC50 values of 2.8, 7.1, 0.2, 3, and 13.7 nM for SST1-5, respectively. Cortistatin-29 is found at similar levels as cortistatin-14 in mouse AtT20 cells but is secreted at a lower level. Cortistatin-29 corresponds to residues 85-112 of the rat peptide sequence.

Veldoreotide (DG3173) TFA，一种生长抑素类似物，能够结合并激活SSTR 2 4 5。其在腺瘤中抑制生长激素分泌的效果相较于Octreotide更为显著。此外，Veldoreotide亦展现出作为镇痛剂的潜力。

Veldoreotide, also known as Somatoprim, is a unique somatostatin receptor subtypes 2-, 4- and 5-selective analogue which effectively reduces GH secretion in human GH-secreting pituitary adenomas, even in Octreotide non-responsive tumours.

MK-1421 is a potent and selective sstr3 antagonist.

Cortistatin 29，一种具备高亲和力结合至所有生长抑素(SS)受体亚型的神经肽，其对SSTR1、SSTR2、SSTR3、SSTR4、SSTR5的IC50值分别为2.8, 7.1, 0.2, 3.0, 13.7 nM。该化合物不仅能减轻神经性疼痛，还表现出抗纤维化作用。

(D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide (Compound 4) 是一种生长抑素类似物，对 SSTR5、SSTR3、SSTR2、SSTR1和 SSTR4的Kd 分别为 0.61、11.05、23.5、1200 和 >1000 nM。