spexin

Potent galanin receptor 2 3 (GAL2 GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by adipocytes and decreas

Spexin TFA, a potent agonist for galanin receptor 2 3 (GAL2 GAL3) with EC50 values of 45.7 and 112.2 nM respectively, shows no significant activity towards galanin receptor 1. As an endogenous peptide promoting satiety, it reduces long chain fatty acid uptake by adipocytes and lowers food consumption in diet-induced obese mice and rats. Additionally, it moderates LH secretion in goldfish and demonstrates anxiolytic effects in vivo.

Spexin-2 (53-70), human, mouse, rat (NPQ 53-70) 是一种在哺乳动物中保守的非酰胺化Spexin-2肽段，具备生物活性。作为新型肽激素proNPQ的一个片段，它在调节心血管与肾功能方面发挥关键作用。在大鼠体内，Spexin-2能有效降低心率并促进尿流量增加。

Spexin acetate(1370290-58-6 free base) 是一种有效的甘丙肽受体 2 3 (GAL2 GAL3) 激动剂（EC50 值分别为 45.7 和 112.2 nM）。对甘丙肽受体 1 没有显着的活性。抑制脂肪细胞对长链脂肪酸的摄取并减少饮食诱导的肥胖小鼠和大鼠的食物消耗。减少金鱼的 LH 分泌。在体内表现出抗焦虑作用。