snx-7

SNX7 (WAY-323879) 是细胞周期蛋白依赖性激酶抑制剂 (CDKI) 途径的抑制剂。 SNX7 可用作研究衰老过程和与 CDKI 相关的其他疾病的工具。

NX-7081 is a novel small molecule inhibitor of Hsp90, which blocks components of inflammation, including cytokine production, protein kinase activity, and angiogenic signaling. SNX-7081 showed strong binding affinity to Hsp90 and expected induction of Hsp70. NF-kappaB nuclear translocation was blocked by SNX-7081 at nanomolar concentrations, and cytokine production was potently inhibited. Growth factor activation of ERK and JNK signaling was significantly reduced by SNX-7081. NO production was also sharply inhibited. In animal models, SNX-4414 fully inhibited paw swelling and improved body weight.

SNX7886为高效CDK8 19蛋白降解剂，在293细胞中可分别降解CDK8与CDK19至90%及80%。