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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21899 |
Misonidazole
SR-1354,SR1354,Ro 7-0582 |
GPX | oxidation-reduction |
Misonidazole 是一种缺氧肿瘤细胞放射增敏剂,具有抗菌活性。 | |||
T2046 |
Nimorazole
Nimorazol,Nitrimidazine,尼莫唑,K-1900,Naxogin,尼莫拉唑 |
Others; Antibiotic; Parasite | Microbiology/Virology; Others |
Nimorazole (Nimorazol) 是一种 2-硝基咪唑,是一种低氧细胞辐射敏化剂。它具有抗感染,抗滴虫等原生动物的作用。它有头颈癌的研究潜力。 | |||
T2607 |
MSDC 0160
CAY10415,Mitoglitazone,MSDC0160,MSDC-0160 |
Others; IGF-1R; Mitochondrial Metabolism | Metabolism; Others; Tyrosine Kinase/Adaptors |
MSDC 0160 (CAY10415) 是一种线粒体丙酮酸载体(MPC) 的调节剂,也是调节噻唑烷二酮的线粒体靶标 (mTOT) 的胰岛素增敏剂。它是一种噻唑烷二酮 (TZD),具有抗糖尿病和神经保护活性作用。它具有用于阿尔茨海默氏病的潜力。 | |||
T5002 |
Methyl Aminolevulinate Hydrochloride
5-Aminolevulinic acid methyl ester,Methyl δ-aminolevulinate hydrochloride,5-氨基酮戊酸甲酯盐酸盐,Methyl 5-aminolevulinate Hydrochloride,Aminolevulinic acid methyl ester Hydrochloride |
Others | Others |
Methyl Aminolevulinate Hydrochloride (5-Aminolevulinic acid methyl ester) 是增敏剂,可用于光动力疗法。Methyl aminolevulinate 是一种前药,可代谢为原卟啉 IX。 | |||
T81483 |
Photosensitizer-2
|
||
Photosensitizer-2 (化合物 1) 是一种带有丙烯酸基团的 D-π-A 光敏剂,显示出高度的光毒性。该化合物对 HeLa 细胞表现出抗肿瘤效果,其半数抑制浓度(IC50)为20.9 ± 4.5 μM(未照光条件下)和0.046 ± 0.012 μM(光照射条件下)。 | |||
T82997 |
Antitumor photosensitizer-2
|
||
Antitumor photosensitizer-2(Compound 11)是一款高效光敏剂,表现出显著的光动力学抗肿瘤活性,并且不具有明显的皮肤光毒性,是光动力学治疗领域新药开发的候选物。 | |||
T75353 | Photosensitizer-1 hydrochloride | ||
Photosensitizer-1 (Compound CLB-13) hydrochloride 是一个光敏剂。 | |||
T75352 | Photosensitizer-1 | ||
Photosensitizer-1 (Compound CLB-13) 是一个光敏剂。 | |||
T79711 |
Antitumor photosensitizer-4
|
Apoptosis | Apoptosis |
Antitumor photosensitizer-4 (compound 10b) 是靶向ABCG2酪氨酸激酶抑制剂(TKI)的有效代表,由达沙替尼与伊马替尼构成的光敏剂(PS)。该化合物能够诱发细胞凋亡(apoptosis)及ROS生成,在HepG2和B16-F10细胞上展现出显著的光毒性作用。 | |||
T82998 |
Antitumor photosensitizer-1
|
||
Antitumor photosensitizer-1(Compound 8)是一种高效的光敏化合物,展现出显著的光动力治疗肿瘤能力,且没有显著的皮肤光毒性反应,是一个潜在的光动力疗法新候选药物。 | |||
T74392 | Antimicrobial photosensitizer-1 | ||
Antimicrobial photosensitizer-1 为抗病原微生物感染的潜在光敏剂,其在金黄色葡萄球菌感染小鼠伤口模型中显示出显著的抗菌活性。 | |||
T74601 | Antitumor photosensitizer-3 | ||
Antitumor photosensitizer-3(Compound I)是一种二氢卟酚衍生物,能在650 nm激光照射下诱导肿瘤细胞的凋亡和坏死。与阳性参考m-THPC相比,Antitumor photosensitizer-3在体内的皮肤光毒性较低。 | |||
T25372 |
EMD57033
EMD-57033,(+)-EMD 57033,EMD 57033 |
Calcium Channel; Carbonic Anhydrase | Membrane transporter/Ion channel; Metabolism |
EMD57033是一种心脏肌钙蛋白C(cTnC)激活剂,是一种显性的Ca2+增敏剂。EMD57033通过与心脏/慢速骨骼肌钙蛋白C 异构体结合从而发挥促进心脏收缩的功能。 | |||
T27303 |
Farglitazar
GI-262570,GI-2570,GW 262570X,GI 262570,GI262570 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Farglitazar (GI-262570) 是一种 PPAR-γ 激动剂,是胰岛素增敏剂,通过氧化物酶体增殖物激活受体γ,抑制星状细胞活化,可用于研究糖尿病。 | |||
T26585 |
AK301
AK-301,AK 301 |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
AK301 是一种强效的管蛋白聚合选择性抑制剂,也是癌细胞对凋亡配体的有效增敏剂(EC50 < 200 nM)。AK301 可阻止有丝分裂的结肠癌细胞在停用化合物并解除阻止后很容易发生 p53 依赖性凋亡。 | |||
T17216 |
Valspodar
PSC 833 |
P-gp | Membrane transporter/Ion channel; Neuroscience |
Valspodar (PSC 833) 是一种特异性的 P-糖蛋白抑制剂和MDR调节剂,常被用作化学增敏剂,可用于研究晚期上皮卵巢癌。 | |||
T4639 |
Azemiglitazone
MSDC 0602 |
Mitochondrial Metabolism; mTOR | Metabolism; PI3K/Akt/mTOR signaling |
Azemiglitazone (MSDC 0602) 是一种 PPARγ 保留的噻唑烷二酮类药物 (TZD),与能够线粒体丙酮酸载体 (MPC) 相互作用并抑制其活性,降低 pparγ 介导的副作用的风险,有用于 2 型糖尿病研究的潜能。 | |||
T0334 |
Rosiglitazone
BRL49653,罗格列酮 |
Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism |
Rosiglitazone (BRL49653) 是一种 PPARγ 激动剂、TRPC5 激活剂和 TRPM3 抑制剂,具有口服活性。Rosiglitazone 也是一种降糖剂,是噻唑烷二酮类胰岛素增敏剂。 | |||
T38715 |
MSDC-0602K
MSDC-0602K,Azemiglitazone potassium |
PPAR | DNA Damage/DNA Repair; Metabolism |
MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both ... | |||
T16785 |
Ropidoxuridine
IPdR |
Others | Others |
Ropidoxuridine (IPdR) 是一种新型的、可口服的卤化胸苷类似物,有望成为人类肿瘤的增敏剂。Ropidoxuridine 是一种可口服且具有生物可利用的IUdR(5-碘-2'-脱氧尿苷)前药。 | |||
T2530 |
Levosimendan
OR1259,OR1855,左西孟旦 |
Potassium Channel; PDE; Carbonic Anhydrase; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Levosimendan (OR1259) 是一种钙增敏剂,通过以钙依赖性方式与心肌肌钙蛋白 C 结合,增加肌细胞对钙的敏感性来发挥其作用,可治疗急性失代偿性充血性心力衰竭。 | |||
T29283 |
1,4-Dibenzyloxybenzene
|
||
1,4-Dibenzyloxybenzene is a aromatic sensitizer. | |||
T34071 |
Piperphentonamine HCl
PPTA |
||
Piperphentonamine HCL is a potential calcium sensitizer for the treatment of heart failure. | |||
T31492 |
Dimethylaminopropyl lauramide
|
||
Dimethylaminopropyl lauramide is a skin sensitizer. | |||
T21270 |
Isometronidazole
R.P. 8979,Isometronidazole, Izoklion |
||
Isometronidazole is a hypoxic cell sensitizer. | |||
T34334 |
RK 29
RK29,RK-29 |
||
RK 29 has hypoxic cell sensitizer properties. | |||
T18960 |
D149 Dye
D149,Indoline dye D149 |
Others | Others |
D149 Dye is an indoline-based dye and a high-extinction-coefficient metal-free organic sensitizer. | |||
T32199 |
ISF-402
ISF 402 |
||
ISF-402 is an insulin sensitizer that may be used in the treatment of type 2 diabetes, dispersing the hexamer insulin in vitro and enhancing the activity of the hexamer insulin more than the monomer liproline insulin. | |||
T19421 |
Methyl aminolevulinate
|
Others | Others |
Methyl aminolevulinate is a prodrug that can be metabolized to Protoporphyrin IX. Methyl aminolevulinate is an agent used as a sensitizer in photodynamic therapy (PDT). | |||
T35265 |
YM-440
YM440,YM 440 |
||
YM-440 is a novel hypoglycemic agent, an insulin sensitizer, that may be used for the treatment of type 2 diabetes mellitus by reducing glucose 6-phosphatase activity in obese Zucker rats and inhibiting liver glucose output through gluconeogenesis. | |||
T35243 |
YD2
YD-2,YD 2 |
||
YD2 is a porphyrin sensitizer. YD2 is a useful material for making solar cell. Cosensitization of YD2-o-C8 with another organic dye enhances the performance of the device, leading to a measured power conversion efficiency of 12.3% under simulated air mass | |||
T70813 |
DTP348
|
||
DTP348 is an oral dual CAIX inhibitor/ radiosensitizer. DTP 348 is an oral dual drug with two mechanisms of action: (1). carbonic anhydrase IX inhibitor which acidifies the intracellular pH through the sulfamide components; (2). radio sensitizer of hypoxic cells through its 5-nitroimidazole moiety. | |||
T69011 | Lobeglitazone | ||
Lobeglitazone, also known as CKD-501, is an antidiabetic drug in the thiazolidinedione class of drugs. As an agonist for both PPARα and PPARγ, it works as an insulin sensitizer by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. | |||
T74089 | Mifamurtide TFA | ||
Mifamurtide TFA (MTP-PE TFA) 是穆拉基二肽 (MDP) 的类似物,一种非特异性免疫调节剂,通过刺激激活巨噬细胞和单核细胞的免疫应答而发挥作用。Mifamurtide TFA 是一种孤儿药,是 NOD2的特异性配体,用作胰岛素增敏剂。Mifamurtide TFA 具有用于骨肉瘤研究的潜力。 | |||
T15748 |
LG100754
UVI 2112 |
PPAR | DNA Damage/DNA Repair; Metabolism |
LG100754 (UVI 2112)是一种通过RXR 发挥作用的胰岛素增敏剂。LG100754是RXR 二聚体调节剂。LG100754是RXR:RXR 同二聚体拮抗剂,以及RXR:PPARα和RXR:PPPARγ异二聚体的激动剂。 | |||
T78463 |
Calconcarboxylic acid
|
||
Calconcarboxylic acid是一种偶氮染料,用作银离子敏化剂,对SDS-PAGE凝胶中的蛋白质条带进行染色。该染料通过与银形成银-染料复合物,促进银与蛋白质的结合,并与甲醛反应增强银离子还原为金属银的过程。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2080 |
Pinoresinol
松脂酚,松脂素,(+)-Pinoresinol |
Apoptosis; NF-κB; CDK; p53 | Apoptosis; Cell Cycle/Checkpoint; NF-κB |
Pinoresinol ((+)-Pinoresinol) 是一种植物来源的木质素,具有抗炎、保肝和杀真菌活性。它导致 CDK 抑制剂 p21(WAF1/Cip1) 在 mRNA 和蛋白质水平上调,抑制 NF-kappaB 和激活蛋白 1 。 | |||
T2S0491 |
Isoeugenol acetate
乙酸异丁香酚酯,Isoeugenyl acetate,Acetisoeugenol,Acetylisoeugenol,乙酸异丁香酚酯,乙酰基异丁香酚;2-甲氧基-4-丙烯基苯基乙酸酯 |
AChE; Antifungal | Microbiology/Virology; Neuroscience |
Isoeugenol acetate (Acetylisoeugenol) 是肉豆蔻,丁香和肉桂的精油成分,对某些代谢酶如乙酰胆碱酯酶,能够抑制α-糖苷酶和 α-淀粉酶。它用于医疗和化妆品工业,具有抗氧化,抗癌,抗菌和抗炎作用。 | |||
T82046 |
Irisquinone
|
||
Irisquinone,一种具有抗癌活性的天然产物,同时作为癌症放射增敏剂。该化合物通过降低GSH水平并抑制DNA单链断裂修复,展现其药理作用。 | |||
TN4997 |
Serpentine
|
IGF-1R | Tyrosine Kinase/Adaptors |
Serpentine 是一种玫瑰花根中的生物碱,可用作胰岛素增敏剂,以协助胰岛素降低血糖。Serpentine 可激活 AMPK 磷酸化,从而刺激C2C12细胞对葡萄糖的摄取。Serpentine 可增加了肌肉组织中GSK-3β mRNA的表达,从而增强葡萄糖摄取。Serpentine 显著增加胰高血糖素分泌和肝糖异生。在高脂肪饮食/链脲佐菌素(HFD/STZ)诱导的糖尿病小鼠中,Serpentine 显著延长了胰岛素的降血糖时间,显著降低了外源性胰岛素的使用,抑制了内源性胰岛素的分泌。 |