saicar

SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner (EC50: 0.3 mM).

N-[(6S)-6-Carboxy-6-(glycylamino)hexanoyl]-D-alanyl-D-alanine，能够干扰PAICS蛋白功能，有效降低SAICAR和SAICAr的积聚。

Adenosine phosphonobutyric, 2'(3'), 5'-diposphate (APBADP) 作为一种抑制剂，对枯草芽孢杆菌 (Bacillus subtilis) 和人腺苷酸琥珀酸裂解酶 (adenylosuccinate lyase (ASL)) 具有显著的抑制作用。此外，Adenosine phosphonobutyric, 2'(3'), 5'-diposphate 还能竞争性抑制琥珀酰氨基咪唑酰胺核苷 (succinylaminoimidazole carboxamide ribotide (SAICAR))，表现出其多功能的生化应用潜力。