rhein 13c4

Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein (T2997) is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM,rhein inhibits IL-1β signaling,suppressing signaling through NF-κB,and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM),decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically increasing TNF-α,IL-1β,and HMBG1 expression.2 Rhein (T2997)shows efficacy against pancreatic fibrosis,chronic pancreatitis,and hyperglycemia-induced pancreatic β-cell apoptosis.3,4 It also inhibits angiogenesis of breast cancer cells under normoxic and hypoxic conditions.5

Rhein (NSC 38629) 从蓼科大黄中提取的一种蒽醌类化合物，有抗炎、抗氧化、抗癌等作用。

Rhein (Standard) 是 Rhein 的标准品。适用于定量分析、质量控制及生化实验等相关研究。Rhein (NSC 38629) 从蓼科大黄中提取的一种蒽醌类化合物，有抗炎、抗氧化、抗癌等作用。