reduced haloperidol

Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 μM, respectively, in COS-7 cells expressing the human transporters). Reduced haloperidol (0.5 mg/kg) increases latency to paw withdrawal in mouse models of capsaicin- but not force-induced mechanical hypersensitivity.

Reduced Haloperidol-d4 是 Reduced Haloperidol 的氘代化合物。Reduced Haloperidol 的 CAS 号为 34104-67-1。

Reduced Haloperidol (Standard) 是一种可用于分析的标准物质，通常用作 Reduced Haloperidol 的研究和分析中参考的标准样品。Reduced haloperidol 是氟哌啶醇的一种活性代谢产物。它是通过酮还原酶对氟哌啶醇进行还原反应而形成的。Reduced haloperidol 能够抑制放射性配体与σ-1受体和多巴胺D2受体的结合（其亲和力分别为 1.4 和 31 纳摩尔），并刺激来自 CCF-SSTG1 和 U87MG 星形胶质细胞的脑源性神经营养因子（BDNF）的分泌。它还能抑制去甲肾上腺素、多巴胺和血清素（5-HT）的再摄取（在表达人类转运蛋白的 COS-7 细胞中，其亲和力分别为 21、25 和 33 微摩尔）。