rat ccr2

PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2 CCR5 antagonist. It also has comparable human and rodent CCR2 potency (rat IC50=20.8 nM). PF-0463481

PF-4136309 (INCB8761) 是一种高效选择性和可口服的 CCR2拮抗剂，能够抑制人、小鼠和大鼠 CCR2，IC50值分别为 5.2、17 和 13 nM。