pt-s 58.

Moexipril methyl ester is a long-acting, non-sulfhydryl angiotensine-converting enzyme inhibitor.

PT-S58 is a PPAR β δ full antagonist, and a derivative of GSK0660. PT-S58 has a three-fold higher affinity for the receptor than GSK0660 and is a potent inhibitor of agonist-induced target gene expression. PT-S58 are effective on PPRE-independent functions of PPARβ δ. Unlike GSK0660, PT-S58 blocks the recruitment co-repressor molecules such as SMRT.